Phytochemical Analysis And The Anti- Inflammatory Activities Of Dichloromethane Fraction Of Methhanol Extract Of Crateva Adansonii
Inflammation is a complex biological response of
vascular tissue to harmful stimuli such as pathogen,
damage cells or irritants (Ryan & Majno, 1983). The
urgency generated by increased rate of stroke,
atherosclerosis attribute due to prolonged use of
cyclooxygenase-1 and Cyclooxygenase- 2 inhibitors
have accelerated anti-inflammatory drug research over
the last decade while synthetic pharmaceutical agents
continued to dominate research (Ryan & Majno, 1983).
Attention increasingly has been directed to natural
products. These are often more affordable and available
and sometimes are perceived as more effective than
conventional anti- inflammatory drugs.
Anti-inflammation was carried out using 12 rats
which was divided into three groups of 4 rats each.
Group 1 and 2 served as the negative and positive
control respectively. Group 3 received 25mg/kg b.w. of
the dichloromethane fraction of methanol extract of
6
Crateva adansonii showed significance anti-inflammatory
activity when compared with the standard difference
used.
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Title page.
Certification.
Dedication
Acknowledgement.
Abstract
Table of Content
CHAPTER ONE
1.1 Introduction
1.2 Crateva adansonii as a plant
1.3 Research aim and objectives.
CHAPTER TWO
LITERATURE REVIEW
2.0 Definition of Inflammation
2.1 Characteristics of Inflammation
2.2 Classes of Inflammation
2.3 Types of Inflammation
2.4 Chemical mediators of Inflammation
2.4.0 Properties of Mediators
2.4.1 Histamine.
2.4.2 Serotonin (5- Hydroxy tryptamine)
2.4.3 Cytokines
2.4.4 Arachidonic acid
2.4.5 Platelet Activating Factor (PAF)
2.4.6 Free Radicals.
2.4.6.1 Nitric Oxide (NO).
2.4.6.2 Oxygen-derived free radicals.
2.4.7.0 Complement system..
2.4.7.1 The clotting system/Coagulation system.
2.4.7.2 The Kinin System.
2.4.7.3 The fibrinolytic system
2.5.0 Anti-Inflammatory agents.
2.5.1 Non-steroidal Anti-inflammatory Drugs (NSAIDS)
2.5.1.0 Mechanism of Action of NSAIDS..
2.5.2 Steroidal Anti-inflammatory drugs.
CHAPTER THREE
MATERIAL AND METHODS
3.1 Materials..
3.1.1 Equipment/Apparatus used.
3.1.2 Chemical, Solvents and Reagent
3.1.3 Animals…
3.2 Methodology..
3.2.1 Collection and preparation of Plant Materials
3.2.2 Extraction
3.3 Fractionation.
3.3.1 Gel Column Chromatography
3.4. Identification of Phytochemical groups
in the extract
3.4.1 Preparation of Reagents for phytochemical analysis.
3.4.2 Qualitative phytochemical analysis
of the Extract.
3.5 Thin Layer Chromatography.
3.6 Anti-inflammatory activity test
CHAPTER FOUR
Result
CHAPTER FIVE
Discussion.
Conclusion.
References.
Appendixes.
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